According to Andrej Karpathy, Command Line Interfaces (CLIs) hold significant potential for AI agents due to their status as 'legacy' technology. This compatibility allows AI tools like Claude or Codex to seamlessly utilize, combine, and interact with CLIs via terminal toolkits. Karpathy emphasizes their utility in enabling AI agents to execute tasks, such as installing and interacting with tools like the Polymarket CLI, enhancing AI-driven workflows.